iSensory Room is an innovative application of Virtual Reality Therapy (VRT). Built upon the CAVE technology, a seamless multi-screen projection, the system renders an immersive VR experience which is engaging, safe, explorative and measurable. Equipped with hybrid sensing technologies, iSensory Room allows children and adults to interact intuitively with the virtual characters and objects by touching or stepping. A variety of multimedia elements such as virtual images, real objects, games, art, music, lighting, sounds and smell are incorporated in the system. iSensory Room offers a series of interactive programs for Multi-Sensory Therapy and Life Skills Training. It provides stimulation and development of 6 senses: Sight, Hearing, Touch, Smell, Vestibular and Proprioception. An unique DIY Content Editor is available for therapists and teachers to develop personalized VR programs for their clients and students.